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Acute inflammatory demyelinating polyradiculoneuropathy(AIDP)

MedGen UID:
1648220
Concept ID:
C4551910
Disease or Syndrome
Synonym: POLYNEUROPATHY, INFLAMMATORY DEMYELINATING, ACUTE
SNOMED CT: Acute inflammatory demyelinating polyneuropathy (26261000119109); Guillain-Barré syndrome acute inflammatory demyelinating polyradiculoneuropathic form (716723000); Acute inflammatory demyelinating polyradiculoneuropathy (716723000)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0020347
OMIM®: 139393
Orphanet: ORPHA98916

Definition

An inflammatory neuropathy belonging to the clinical spectrum of Guillain-Barré syndrome. The clinical course is divided into three phases. The first phase (lasting a few weeks) has characteristics of rapidly progressive muscle weakness. It is symmetrical and may cause acute neuromuscular paralysis. Sensory disturbances, intense pains, and cramps may also occur. During the second phase (variable duration), symptoms become stable but other manifestations (cardiac arrhythmias, hyper/hypotension and gastric dysmotility) may occur. During the third (recovery) phase, lasting a few months or longer, symptoms slowly regress. Many patients have residual findings (weakness, sensory disturbances, fatigue or pain) for many months or even years. In the majority of cases, an infectious disease precedes the onset of limb weakness, with Campylobacter jejuni infection being the most frequent initiating event. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute inflammatory demyelinating polyradiculoneuropathy

Professional guidelines

PubMed

Hughes RAC
Eur J Neurol 2024 Nov;31(11):e16346. Epub 2024 May 16 doi: 10.1111/ene.16346. PMID: 38752584Free PMC Article
Sudulagunta SR, Sodalagunta MB, Sepehrar M, Khorram H, Bangalore Raja SK, Kothandapani S, Noroozpour Z, Aheta Sham M, Prasad N, Sunny SP, Mohammed MD, Gangadharappa R, Nidsale Sudarshan R
Ger Med Sci 2015;13:Doc16. Epub 2015 Sep 21 doi: 10.3205/000220. PMID: 26421004Free PMC Article
Sederholm BH
Semin Neurol 2010 Sep;30(4):365-72. Epub 2010 Oct 12 doi: 10.1055/s-0030-1267280. PMID: 20941669

Recent clinical studies

Etiology

Zubair AS, Rethana M, Ma A, McAlpine LS, Abulaban A, Munro BS, Patwa HS, Nowak RJ, Roy B
J Clin Neuromuscul Dis 2023 Sep 1;25(1):11-17. doi: 10.1097/CND.0000000000000439. PMID: 37611265
Sudulagunta SR, Sodalagunta MB, Sepehrar M, Khorram H, Bangalore Raja SK, Kothandapani S, Noroozpour Z, Aheta Sham M, Prasad N, Sunny SP, Mohammed MD, Gangadharappa R, Nidsale Sudarshan R
Ger Med Sci 2015;13:Doc16. Epub 2015 Sep 21 doi: 10.3205/000220. PMID: 26421004Free PMC Article
Ansar V, Valadi N
Prim Care 2015 Jun;42(2):189-93. Epub 2015 Mar 20 doi: 10.1016/j.pop.2015.01.001. PMID: 25979580
Walling AD, Dickson G
Am Fam Physician 2013 Feb 1;87(3):191-7. PMID: 23418763
Juel VC, Massey JM
Orphanet J Rare Dis 2007 Nov 6;2:44. doi: 10.1186/1750-1172-2-44. PMID: 17986328Free PMC Article

Diagnosis

Miranda C, Brannagan TH 3rd
Handb Clin Neurol 2023;195:619-633. doi: 10.1016/B978-0-323-98818-6.00026-1. PMID: 37562890
Bortoluzzi A, Silvagni E, Furini F, Piga M, Govoni M
Clin Exp Rheumatol 2019 Jan-Feb;37(1):146-155. Epub 2018 May 24 PMID: 29846158
Sudulagunta SR, Sodalagunta MB, Sepehrar M, Khorram H, Bangalore Raja SK, Kothandapani S, Noroozpour Z, Aheta Sham M, Prasad N, Sunny SP, Mohammed MD, Gangadharappa R, Nidsale Sudarshan R
Ger Med Sci 2015;13:Doc16. Epub 2015 Sep 21 doi: 10.3205/000220. PMID: 26421004Free PMC Article
Walling AD, Dickson G
Am Fam Physician 2013 Feb 1;87(3):191-7. PMID: 23418763
Hughes RA, Cornblath DR
Lancet 2005 Nov 5;366(9497):1653-66. doi: 10.1016/S0140-6736(05)67665-9. PMID: 16271648

Therapy

Chakraborty T, Kramer CL, Wijdicks EFM, Rabinstein AA
Neurocrit Care 2020 Feb;32(1):113-120. doi: 10.1007/s12028-019-00781-w. PMID: 31297663
Sudulagunta SR, Sodalagunta MB, Sepehrar M, Khorram H, Bangalore Raja SK, Kothandapani S, Noroozpour Z, Aheta Sham M, Prasad N, Sunny SP, Mohammed MD, Gangadharappa R, Nidsale Sudarshan R
Ger Med Sci 2015;13:Doc16. Epub 2015 Sep 21 doi: 10.3205/000220. PMID: 26421004Free PMC Article
Ansar V, Valadi N
Prim Care 2015 Jun;42(2):189-93. Epub 2015 Mar 20 doi: 10.1016/j.pop.2015.01.001. PMID: 25979580
Walling AD, Dickson G
Am Fam Physician 2013 Feb 1;87(3):191-7. PMID: 23418763
Hughes RA, Cornblath DR
Lancet 2005 Nov 5;366(9497):1653-66. doi: 10.1016/S0140-6736(05)67665-9. PMID: 16271648

Prognosis

Miranda C, Brannagan TH 3rd
Handb Clin Neurol 2023;195:619-633. doi: 10.1016/B978-0-323-98818-6.00026-1. PMID: 37562890
Chakraborty T, Kramer CL, Wijdicks EFM, Rabinstein AA
Neurocrit Care 2020 Feb;32(1):113-120. doi: 10.1007/s12028-019-00781-w. PMID: 31297663
Sudulagunta SR, Sodalagunta MB, Sepehrar M, Khorram H, Bangalore Raja SK, Kothandapani S, Noroozpour Z, Aheta Sham M, Prasad N, Sunny SP, Mohammed MD, Gangadharappa R, Nidsale Sudarshan R
Ger Med Sci 2015;13:Doc16. Epub 2015 Sep 21 doi: 10.3205/000220. PMID: 26421004Free PMC Article
Walling AD, Dickson G
Am Fam Physician 2013 Feb 1;87(3):191-7. PMID: 23418763
Hughes RA, Cornblath DR
Lancet 2005 Nov 5;366(9497):1653-66. doi: 10.1016/S0140-6736(05)67665-9. PMID: 16271648

Clinical prediction guides

Kalita J, Kumar M, Misra UK
Neurol India 2022 Sep-Oct;70(5):1995-2002. doi: 10.4103/0028-3886.359245. PMID: 36352600
Oliveira DRDCAB, Fernandez RNM, Grippe TC, Baião FS, Duarte RL, Fernandez DJ
Arq Neuropsiquiatr 2021 Jun;79(6):497-503. doi: 10.1590/0004-282X-ANP-2020-0314. PMID: 34320055Free PMC Article
Chakraborty T, Kramer CL, Wijdicks EFM, Rabinstein AA
Neurocrit Care 2020 Feb;32(1):113-120. doi: 10.1007/s12028-019-00781-w. PMID: 31297663
Lakshminarasimhan S, Venkatraman C, Vellaichamy K, Ranganathan L
J Clin Neurophysiol 2018 Sep;35(5):415-418. doi: 10.1097/WNP.0000000000000480. PMID: 29847438
Sudulagunta SR, Sodalagunta MB, Sepehrar M, Khorram H, Bangalore Raja SK, Kothandapani S, Noroozpour Z, Aheta Sham M, Prasad N, Sunny SP, Mohammed MD, Gangadharappa R, Nidsale Sudarshan R
Ger Med Sci 2015;13:Doc16. Epub 2015 Sep 21 doi: 10.3205/000220. PMID: 26421004Free PMC Article

Recent systematic reviews

Abuawwad MT, Taha MJJ, Taha AJ, Kozaa YA, Falah O, Abuawwad IT, Hammad EM, Mahmoud AA, Aladawi M, Serhan HA
Clin Neurol Neurosurg 2024 Mar;238:108183. Epub 2024 Feb 20 doi: 10.1016/j.clineuro.2024.108183. PMID: 38401232
Sriwastava S, Kataria S, Tandon M, Patel J, Patel R, Jowkar A, Daimee M, Bernitsas E, Jaiswal P, Lisak RP
J Neurol Sci 2021 Jan 15;420:117263. Epub 2020 Dec 9 doi: 10.1016/j.jns.2020.117263. PMID: 33321326Free PMC Article
Wachira VK, Peixoto HM, de Oliveira MRF
Trop Med Int Health 2019 Feb;24(2):132-142. Epub 2018 Dec 18 doi: 10.1111/tmi.13181. PMID: 30444562

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